I’m QiaoMei, with over 25+ years of expertise in OEM, ODM and private label cosmetics, focusing on crafting high-quality HairCare Skincare BodyCare and makeup products with unparalleled insights into formulation, quality and market trends
Introduction
Today’s consumers commonly face a range of hair concerns, including damage from coloring and perming, fragile strands, frizz, dryness, and slow growth. Traditional hair care ingredients often provide only superficial repair, failing to penetrate the scalp’s microenvironment to deliver fundamental improvement.
This raises a critical question: Is there an ingredient capable of mimicking cellular signals to target the hair root and scalp ecosystem directly, achieving genuine “root-level” restoration from the source?
As a leading enterprise in the cosmetics industry, Qiaomei Cosmetics is dedicated to the cross-boundary innovation of cutting-edge ingredients. Today, we introduce a revolutionary component derived from regenerative medicine — PDRN (Polydeoxyribonucleotide) — and its groundbreaking application in the field of hair care.
The Source of PDRN:
PDRN (Polydeoxyribonucleotide) is a polynucleotide preparation consisting of short-fragment DNA. It is commonly sourced and purified from cold-water fish (such as salmon). In medicine, PDRN is utilized as a reconstructive/reparative biomolecule to promote tissue regeneration, offering anti-inflammatory and anti-ischemic effects. It has a well-documented history of research and clinical application, particularly in dermatology, aesthetic medicine, and wound healing. With advancing technology, PDRN’s applications are now extending into the hair care industry.
PDRN's Core Repair Mechanism
RN’s Core Repair Mechanism
The fundamental restorative mechanism of PDRN stems from its high biocompatibility with human cells. When applied to the scalp, PDRN delivers an efficient “repair signal” to hair follicle stem cells and scalp fibroblasts by activating the critical Adenosine A2A Receptor (A2AR) pathway. This process is analogous to “recharging” fatigued cells.
- Activation of the Adenosine A2A Receptor (A2AR): A key biological action of PDRN is the activation of the Adenosine A2A Receptor. This triggers downstream signaling that inhibits inflammation and promotes angiogenesis (blood vessel formation) and cell proliferation. A2AR signaling is associated with the upregulation of VEGF (Vascular Endothelial Growth Factor) expression, thereby supporting the formation of new blood vessels.
- Providing Nucleotide Fragments as “Repair Substrates”: PDRN is recognized for supplying deoxyribonucleotide fragments to damaged tissues. These fragments act as essential substrates, supporting damaged cells in DNA repair/replication and metabolic processes, which in turn accelerates the overall repair mechanism.
- Regulation of Apoptosis and Proliferation Genes: Preclinical studies indicate that PDRN can downregulate pro-apoptotic pathways while upregulating pro-proliferation and survival factors. This regulation favors the survival and vitality of hair follicle cells.
The 5 Key Efficacy Benefits of PDRN in Scalp/Hair Care
PDRN works through multiple synergistic mechanisms to effectively improve hair loss and promote healthy hair growth. Its core functions include: promoting hair follicle angiogenesis by upregulating vascular endothelial growth factor (VEGF) to improve perifollicular microcirculation and enhance nutrient delivery, thereby supporting the maintenance of the hair growth phase; stimulating hair follicle cell proliferation and regeneration by activating specific receptor signaling pathways to promote cell growth and reduce apoptosis, thereby restoring hair follicle function; exerting anti-inflammatory and immunomodulatory effects by activating anti-inflammatory pathways and downregulating inflammatory factors, alleviating the adverse effects of chronic low-grade inflammation on hair follicles; and promoting tissue repair and matrix generation by stimulating collagen synthesis and tissue remodeling, improving scalp structure and skin barrier function. Notably, studies show that the combined application of PDRN with other therapies such as PRP can produce synergistic effects, further enhancing hair density and hair shaft diameter in the treatment of androgenetic alopecia and female pattern hair loss.
Efficacy Dimension | Specific Manifestation |
1. Hair Follicle Activation | Stimulates telogen hair follicles to enter the anagen phase, increasing hair density. Clinical studies show that after 12 weeks of use, the number of new hairs in balding areas increases by an average of 30%–40%. |
2. Anti-Hair Loss & Hair Growth | Improves the hair follicle microenvironment (e.g., nutrient supply, inflammatory status) and reduces hair loss. It is particularly effective as an adjuvant treatment for androgenetic alopecia and alopecia areata. |
3. Hair Repair | Repairs the keratin structure of damaged hair strands, reducing split ends and breakage, making hair stronger and more lustrous. It is especially effective for chemically treated (e.g., permed/dyed) or dry, damaged hair. |
4. Scalp Anti-Inflammation | Alleviates symptoms such as seborrheic dermatitis, scalp itching, and redness, improving the scalp’s health environment. It reduces inflammation-mediated hair loss risk. |
5. Scalp Moisturization | Promotes the repair of the scalp barrier, enhances moisture retention capacity, and relieves dryness and scaling. It functions similarly to a “scalp moisturizer + repair agent” with dual effects. |
Clinical Evidence
- Early/Mid-Stage Clinical Studies: Multiple clinical studies and case series reports indicate that localized (intra-perifollicular or intradermal) injection of PDRN, either alone or combined with PRP, leads to statistically significant improvements in average hair count and hair diameter. For example, one study involving female subjects reported significant increases in both hair count and thickness after 12 sessions of PDRN-only injections.
- Recent Randomized/Prospective Studies & Injectable Polynucleotide Gels: Trials published in 2024 and later (involving small sample sizes and short-to-mid-term follow-up) also support the finding that injections of polynucleotides (including PDRN/PN) can reduce hair loss, increase hair density, and are well-tolerated. However, the overall sample sizes and follow-up durations remain limited, necessitating larger-scale, longer-term randomized controlled trials for further validation.
- Systematic Review Perspectives: In reviews discussing regenerative therapies for Androgenetic Alopecia (AGA), polynucleotides are categorized as a “promising alternative or adjunctive therapy.” Nonetheless, authors note that the evidence grade remains weaker compared to conventional treatments like PRP, minoxidil, or finasteride, underscoring the need for more high-quality RCTs.
The Market Landscape of PDRN Hair Care
Currently, PDRN (Polydeoxyribonucleotide) is widely used in skincare products such as toners, creams, and serums, but its application in hair care remains a blue ocean with very few mature products available. This significant market gap indicates substantial untapped potential.
Qiaomei Cosmetics, with its forward-looking vision, has identified this opportunity. We believe that early deployment of private-label PDRN hair care products will not only help seize first-mover advantages and capture consumer mindshare but also build a technological barrier in the highly competitive market, thereby enhancing brand visibility and unlocking new growth opportunities.
The popularity of products like the VT PDRN Reedle Shot Scalp Shampoo has preliminarily validated the strong market demand and high acceptance of high-end PDRN hair care ingredients. This presents an ideal entry opportunity—and now, the market is waiting for a better solution.
VT PDRN Reedle Shot Scalp Hair Care Products
Benefits of PDRN Shampoo: Scalp Reset for Thinning Hair, Hair Loss & Early-Stage Baldness。PDRN Shampoo & Scalp Treatment offers an intensive care solution designed to reactivate fatigued hair follicles, restore scalp balance, and create optimal conditions for stronger, fuller hair — before it’s too late. Powered by regenerative active ingredients such as PDRN, EGF, and FGF, this ampoule-style formula helps improve long-term scalp health and hair retention.
🔬 Key Ingredients
- PDRN (5000 ppm): Supports skin and scalp regeneration.
- EGF & FGF: Enhance elasticity and repair.
- Centella Asiatica (Cica/Gotu Kola): Soothes, exfoliates, and strengthens the hair shaft.
- Copper Tripeptide-1: Supports a healthy hair growth cycle.
- Biotin, Niacinamide, Panthenol: Strengthen, moisturize, and protect.
QM Cosmetic PDRN Shampoo
this product is specifically designed to address thinning hair, hair loss, and early-stage baldness. Infused with potent active ingredients, it penetrates deeply to revitalize fatigued, dormant hair follicles and restore a healthy scalp environment. This process establishes a solid foundation for stronger, fuller hair growth, helping you seize the critical window for effective hair care. Powered by core ingredients like PDRN, caffeine, and castor oil, biotin, this formula works synergistically to improve scalp health at the root cause, promoting hair retention and density.
The global PDRN shampoo market size was approximately USD 500 million in 2022, with a projected compound annual growth rate (CAGR) of 18% – 22% from 2023 to 2028 (Source: Grand View Research).
Regional Market: The Asia-Pacific region (particularly China, South Korea, and Japan) is the core growth area. China’s market size was approximately USD 120 million in 2022 and is expected to exceed USD 400 million by 2026 (Key drivers: Increasing hair loss among younger populations and rising demand for advanced hair care solutions).
FAQ About PDRN Private Lable Cosmetic
PDRN shows significant effects for telogen effluvium, androgenetic alopecia (as an adjunct therapy), and alopecia areata (early intervention). However, for hereditary hair loss (such as severe androgenetic alopecia), it needs to be combined with medications (like minoxidil, finasteride) or other therapies (such as microneedling or PRP).
A: Clinical studies indicate that topical PDRN has a high safety profile. A small number of people might experience mild scalp irritation (such as redness or itching), which usually subsides after discontinuing use. Pregnant or breastfeeding women are advised to consult a doctor before use.
A: The role of PDRN is to “activate hair follicles + repair hair quality.” Short-term use (4-8 weeks) can improve symptoms, but long-term use (e.g., continuously for 6 months) can help maintain hair follicle health and hair quality stability, preventing recurrence.
A: Minoxidil: Promotes hair growth by dilating blood vessels; primarily used topically and requires long-term use (hair loss may recur after stopping).
Finasteride: Inhibits 5-alpha reductase; an oral medication for men only, with potential sexual function side effects.
PDRN: Repairs at the cellular level; can be used both topically and via injection; has high safety and is suitable for long-term maintenance of hair follicle health.
A: The concentration in topical products (e.g., shampoos, serums) is typically 1% – 5% (higher concentrations may irritate the scalp). Medical-grade products (e.g., injectable PDRN) have higher concentrations (10% – 20%) but must be administered by a professional doctor.
Different Forms of Hair Care Products and Their Specific Functions
Understanding ingredients is the first step, but choosing the correct product form is key to delivering those ingredients precisely to the target area. Just like skincare requires a coordinated routine of “toner, emulsion, serum, and mask,” scalp and hair health also need a complete care system. Common product forms include shampoo, conditioner, hair mask, scalp scrub, hair oil, and scalp serum.
1. Shampoo
- Core Efficacy: Cleanses the scalp and hair strands, removing sebum, dirt, and product buildup. It opens absorption channels for subsequent treatments.
- Ingredients & Form Characteristics: Liquid texture, short contact time (minutes). Key ingredients focus on immediate cleansing, anti-dandruff, oil control, and soothing (e.g., Zinc Pyrithione, Salicylic Acid, mild surfactants). Anti-hair loss shampoos primarily prepare the foundation, improve the scalp environment, and assist with oil control. Due to the short rinse-off time, the addition of high concentrations of active ingredients is of limited significance.
2. Daily Maintenance: Conditioner / Hair Mask
- Core Efficacy: Neutralizes negative charge, smoothes the cuticle, provides instant softness and shine, and reduces friction.
- Ingredients & Form Characteristics:
- Conditioner has a creamy texture; hair masks are richer. Leave-on time is slightly longer (3-5 minutes to 15 minutes).
- Core ingredients include cationic conditioners, silicones, proteins, and humectants.
3. Intensive Treatment: Scalp Serums / Hair Growth Solutions
- Core Efficacy: Targeted treatment for scalp issues and core stimulation for hair growth. This is the “main battlefield” for high-concentration active ingredients.
- Ingredients & Form Characteristics: Lightweight liquid or serum texture, leave-in (not rinsed), remains on the scalp for hours/overnight.
The 10 key ingredients previously discussed (e.g., Minoxidil, Caffeine, PDRN, Peptides) are most suitable in this form. It maximizes the transdermal absorption of active ingredients, allowing them to act directly on hair follicles. This is the most effective product form for significant anti-hair loss and hair growth results.
4. Periodic Care: Scalp Scrubs / Cleansing Masks
- Core Efficacy: Deep cleansing, exfoliating dead skin cells, unclogging follicles, and relieving scalp itch.
- Ingredients & Form Characteristics:
- Contains physical exfoliants (e.g., sea salt, sugar) or chemical exfoliants (e.g., AHAs, BHA/Salicylic Acid).
Used 1-2 times weekly for a “deep clean,” removing buildup to enhance the absorption of subsequent serums.
5. Instant Nourishment: Hair Oils
- Core Efficacy: Forms a protective film on the hair surface, locks in moisture, shields against heat damage, and provides high shine.
- Ingredients & Form Characteristics:
- Primarily composed of various plant oils (e.g., Argan, Coconut, Camellia oil).
Applied to the ends of dry hair to create smoothness and shine. Generally not applied directly to the scalp (unless specifically formulated as a scalp treatment oil).
Finding the Right OEM/ODM/Private Label Hair Crea Manufacturer in China
Every world-class brand struggled with finding the right skincare/cosmetic manufacturer. Some were lucky and found long-term partners, while others had a hard time finding the right one.
China has become a world leader in manufacturing. But there are a lot of OEM manufacturers who have made a lot of promises but failed to deliver. How do you make sure that you have made the right choice?
Start with the basics
You have contacted several OEM manufacturers and are studying their quotes. But choosing the right provider goes beyond numbers. You might save a few thousand dollars, but the provider fails you in many other areas. That can cost you more. So, finding the right balance between price and quality is very important to you.
Look at their commitment
Your OEM/Private Label partner should be an asset to your company. In order to have a good working relationship, their beliefs and procedures should align with yours. Look at the level of service they offer. Also, look at the other expertise they bring to the table. If that expertise is important to you, make sure the provider you choose has that.
Get to know your OEM
Once you have shortlisted your options, take action and visit each of the manufacturers on your list. Get to know the people who manage and work there. Get a feel for what it’s going to be like working with them. Can they deliver from start to finish?
5Reasons to Choose QM Cosmetic as Your Private Label/OEM Partner
1. Hassle-Free
We provide one-stop professional OEM service solutions from formulation customization to packaging design and production. We take care of the nitty-gritty so you can focus on building your brand and establishing your sales channels.
2. Quality Management
All of our products are manufactured in a 100,000-grade clean room built to international GMPC standards. We have a team of experienced and professional and strict staff to carry out daily inspection of the items that have been produced.
3. Rigorous Production Process
QM Cosmetic ensures that every step of the production process is carefully managed and inspected using detailed Standard Operating Procedures. We have put product inspection standards in place to make sure quality requirements have been complied.
4. Experienced R&D Team
Our experts in OEM Cosmetics & Skincare Research team are the essential foundation to make your success. We have thousand of formulations for a wide range of skincare products. Learn more about this team and other teams.
5 Natural thermal water resource—the only one in Asia, one of only two in the world.
As the pioneer and industry leader in natural thermal spring water ingredients for the global cosmetics sector, we hold exclusive rights to a precious natural thermal water resource—the only one in Asia, one of only two in the world.
Over the past 25+ years, we have partnered with top laboratory teams across multiple countries to jointly establish application standards for thermal spring water in cosmetics and build a comprehensive R&D and efficacy verification system for ingredients.
Our core strengths are built upon three pillars:
- Resource Exclusivity: Control over one of only two globally recognized natural active thermal spring water sources, and the sole such resource in Asia.
- Scientific Authority: Long-term collaborative partnerships with leading research institutions in France, Japan, and Switzerland.
- Proven Expertise: 25 years of specialized focus on thermal spring water ingredient R&D, coupled with active participation in establishing industry standards.
We remain committed to transforming this natural endowment into safe and effective cosmetic ingredients through scientific innovation, delivering unique solutions for global brands. Every achievement is grounded in rigorous scientific validation, maintaining our authoritative position in the field of thermal spring water skincare.
